|ARTHRITIS VITAMINS - AN OVERVIEW
Arthritis Vitamin and Healthy Joints and Bones
This exceptional Health Formula was produced with the finest raw materials and highest standards of manufacturing in mind guaranteeing %100 absorption. This product mainly contains Chondroitin Sulfate, Glucosamine Sulfate, and MSM (methysulphonylmethane). Chondroitin and Glucosamine sulfates are substances incorporated in the articular cartilages and the building structure of joints. MSM, the natural source of sulfur, which is one of the components of every cell, has anti-arthritic effects and fights joint ache and inflammations while helping mobility. Consequently, supplying these substances to your body will increase its health potential to confront arthritis, joint troubles, reduce stiffness and improve joint mobility, while accelerating cartilage regeneration and reducing joint aches. In addition, 14 amino acids, the "Building Blocks of Life", have been incorporated into this "Highly Specialized Health Formula".
The reasoning for the formulation of this extraordinary effervescent product is the logic behind the health benefits of its key ingredients, simply Chondroitin, Glucosamine and MSM. Consequently, it seems to be best to discuss each and every one of them and their benefits in the following categorized manner for your better understanding.
Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). It is usually found attached to proteins as part of a proteoglycan. Understanding the functions of such diversity in chondroitin sulfate and related glycosaminoglycans is a major goal of glycobiology. Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression. Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis.
Most chondroitin is made from extracts of cartilaginous cow and pig tissues (cow trachea and pig ear and nose), but other sources such as shark, fish and bird cartilage are also used. Clinical studies have not identified any significant side effects or overdoses of chondroitin sulfate, which supports its long-term safety. Actually, the Task Force of the European League Against Rheumatism (EULAR) committee recently granted chondroitin sulfate a level of toxicity of 6 in a 0-100 scale, confirming it is one of the safest drugs for osteoarthritis. Moreover, its safety is supported by an absence of drug to drug interactions (chondroitin sulfate is not metabolized by cytochrome P450), and the lack of safe alternatives for patients multi-medicated for osteoarthritis and other accompanying diseases, e.g. diabetes, hypertension, hyperlipidemia, etc.
Chondroitin sulfate has shown in several prospective controlled studies clinical benefits to decrease pain, improve functional disability, reduce NSAID or acetaminophen consumption, and good tolerability with an additional carry over effect. A review by Bruyere et al. about glucosamine and chondroitin sulfate for the treatment of knee and hip osteoarthritis concludes that both products act as valuable symptomatic therapies for osteoarthritis disease with some potential structure modifying effects.
Currently OARSI (OsteoArthritis Research Society International) is recommending chondroitin sulfate as the second most effective treatment for moderate cases of osteoarthritis. Likewise, the European League Against Rheumatism (EULAR) supports the usefulness of chondroitin sulfate in the management of knee osteoarthritis and grants the highest level of evidence, 1A, and strength of the recommendation, A, to this product.
Glucosamine (C6H13NO5) is an amino acid sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine is found as a major component of the exoskeletons of crustaceans and other arthropods, in fungi and many higher organisms and is one of the most abundant monosaccharides. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine does help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe. Glucosamine is usually derived from shellfish. Those allergic to shellfish may wish to avoid it. However, since glucosamine is derived from the shells of these animals while the allergen is within the flesh of the animals, it is probably safe even for those with shellfish allergy.
The benefit of glucosamine sulfate in patients with osteoarthritis is the result of a number of effects including its anti-inflammatory activity, the stimulation of the synthesis of proteoglycans, and the decrease in catabolic activity of chondrocytes inhibiting the synthesis of proteolytic enzymes and other substances that contribute to damage cartilage matrix and cause death of articular chondrocytes.
Multiple clinical trials in the 1980s and 1990s, all sponsored by the European patent-holder, Rottapharm, demonstrated a benefit for glucosamine. He sponsored two large (at least 100 patients per group), three-year-long, placebo-controlled clinical trials of the Rottapharm brand of glucosamine sulfate. These studies both demonstrated a clear benefit for glucosamine treatment. There was not only an improvement in symptoms but also an improvement in joint space narrowing on radiographs. This suggested that glucosamine, unlike pain relievers such as NSAIDSs, can actually help prevent the destruction of cartilage that is the hallmark of osteoarthritis.
Some reviews and meta-analyses have evaluated the efficacy of glucosamine. Richy and Col performed a meta-analysis of randomized clinical trials in 2003 and found efficacy for glucosamine on VAS and WOMAC pain, Lequesne index and VAS mobility and good tolerability. Even recently, a review by Bruyere et al. about glucosamine and chondroitin sulfate for the treatment of knee and hip osteoarthritis concludes that both products act as valuable symptomatic therapies for osteoarthritis disease with some potential structure-modifying effects.
MSM is a naturally occurring organic sulfur compound. It is present in fish, meat, plants and fruits. Methylsulfonylmethane is a chemical compound (organic sulfur compound) that is required for the development and maintenance of connective and other type of tissues. MSM is found throughout our body in nails, skin, tissues and much more (as MSM is an important building block of the hairs and tissues).
In the past few years, Methylsulfonylmethane (MSM) has become well recognized amongst people suffering from various problems such as different types of allergies, inflammations, heartburns, fibromyalgia, arthritis rhinitis, hair problems (those with keratin level in hair below normal), joint pain, parasitic infection, irritable bowel syndrome, carpal tunnel syndrome and also skin and nails related issues. MSM has proven itself to be highly advantageous in strengthening joints, balancing blood flow as it helps in increasing the blood flow, muscle contraction problem and other mobility related problems.
MSM in combination with Glucosamine, Chondroitin have shown extremely positive results for patient suffering from joint pain. It now also believed to have an important role to play in treatment of cancer (it helps in reducing growth of some type of carcinogen cells) and Seasonal Allergic Rhinitis (SAR) as MSM helps in fighting symptoms of these diseases. Of course, more study in this area is still needed.
MSM and its effects on human health is still a subject of many researches. Fortunately, there has been no discovery of a prominent side effect caused by MSM to this time.
Iceberg Laboratories, Inc. is a formulator and manufacturer of the finest pharma quality, small molecularly structured “Effervescent Dietary Health Supplements”. Our exclusive products are formulated to be fully buffered, perfectly balanced, 100% absorbable and with a refreshing taste will give you an immediate boost of physical and mental energy every time!
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